| Product Name | Tivantinib | ARQ-197 |
|---|---|
| CAS | 905854-02-6 |
| Formula | C23H19N3O2 |
| MW | 369.42 |
| Appearance | Light brown to brown powder |
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
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| Product Name | Tivantinib | ARQ-197 |
|---|---|
| CAS | 905854-02-6 |
| Formula | C23H19N3O2 |
| MW | 369.42 |
| Appearance | Light brown to brown powder |
Tivantinib is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.
PMID: 20484018 DOI: 10.1158/1535-7163.MCT-09-1173