Ropivacaine

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Product Overview

Product Name	Ropivacaine
CAS	84057-95-4
Formula	C17H26N2O
MW	274.40
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

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Product details

Ropivacain is a potent sodium channel blocker. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain management.

Related literature

Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain.

PMID: 16392884 DOI: 10.2165/00003495-200565180-00013

PMID: 30822427 DOI: 10.1016/j.lfs.2019.02.053

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PMID: 25617901 PMCID: PMC4305322 DOI: 10.1371/journal.pone.0117321