CX-5461 dihydrochloride

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	CX-5461 dihydrochloride
CAS	N/A
Formula	C27H27N7O2S·2HCl
MW	586.54 \| 513.62(free)
Appearance	Light yellow to yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC₅₀s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC₅₀ ≥25 μM).

Related literature

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

PMID: 21159662 DOI: 10.1158/0008-5472.CAN-10-1728

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53.

PMID: 22789538 PMCID: PMC3749732 DOI: 10.1016/j.ccr.2012.05.019