BAN ORL 24 | 1401463-54-4

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
CAS	1401463-54-4
Formula	C27H35N3O2·2HCl
MW	506.51 \| 433.60 (free)
Appearance	White to off-white powder
Storage condition	-20°C, protect from light, stored under nitrogen

Product details

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (K_i = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (K_is = 0.19, 0.34, and >1 µM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA₂ = 9.98) and calcium mobilization (K_B = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of µ-opioid and NOP receptors BPR1M97 in mice.

Related literature

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.

https://doi.org/10.1016/j.neuropharm.2019.107678

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24.

PMID: 19445927 DOI: 10.1016/j.ejphar.2009.04.054