NVP-TAE 684 | TAE 684 | CAS 761439-42-3

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Availability

Price(USD)

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Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	NVP-TAE 684 \| TAE 684
CAS	761439-42-3
Formula	C30H40ClN7O3S
MW	614.20
Appearance	Light yellow to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC₅₀ values between 2 and 10 nM.

Related literature

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

PMID: 17185414 PMCID: PMC1765448 DOI: 10.1073/pnas.0609412103

Therapeutic strategies to overcome PF-02341066 resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.

PMID: 21502504 PMCID: PMC3088626 DOI: 10.1073/pnas.1019559108

Activating ALK mutations found in neuroblastoma are inhibited by PF-02341066 and NVP-TAE684.

PMID: 21838707 DOI: 10.1042/BJ20101796

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History

CL3084

NVP-TAE 684 | TAE 684

761439-42-3 98+%

NVP-TAE 684 | TAE 684

Chemical safety data sheet(MSDS)