| Product Name | Suzetrigine (Synonyms: VX-548) | 
|---|---|
| CAS | 2649467-58-1 | 
| Formula | C21H20F5N3O4 | 
| MW | 473.39 | 
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | 
|---|---|---|---|---|
| 1 mg | 3-5 days | $466.00 | Visible after login | |
| 5 mg | 3-5 days | $1066.00 | Visible after login | 
| Product Name | Suzetrigine (Synonyms: VX-548) | 
|---|---|
| CAS | 2649467-58-1 | 
| Formula | C21H20F5N3O4 | 
| MW | 473.39 | 
Suzetrigine (VX-548) is a selective NaV1.8 inhibitor with oral bioavailability, acting as a potent analgesic. It targets the sodium channel protein type 10 subunit alpha, playing a key role in pain transmission. This drug candidate shows promise in acute pain management post-abdominoplasty and bunionectomy, presenting as a non-opioid analgesic option.
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Gender difference in the pharmacokinetics and metabolism of VX-548 in rats.
PMID: 38573807 DOI: 10.1002/bdd.2387
Biomed Chromatogr. 2024 Jul;38(7):e5907.
Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.
PMID: 37530822 DOI: 10.1056/NEJMoa2209870