PLX5622; CAS: 1303420-67-8

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	$56.00	Visible after login	- +
5 mg	3-5 days	$138.00	Visible after login	- +
10 mg	3-5 days	$196.00	Visible after login	- +
25 mg	3-5 days	$326.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5 days

$56.00

Visible after login

- +

5 mg

3-5 days

$138.00

Visible after login

- +

10 mg

3-5 days

$196.00

Visible after login

- +

25 mg

3-5 days

$326.00

Visible after login

- +

Product Overview

Product Name	PLX5622
CAS	1303420-67-8
Formula	C21H19F2N5O
MW	395.41
MDL	MFCD32201039

Product details

PLX5622, a highly selective CSF-1R inhibitor with an IC50 of < 10 nmol/L and over 20-fold selectivity over KIT and FLT3, is a brain-penetrant, orally active compound with an IC50 of 0.016 μM and a Ki of 5.9 nM. It enables targeted microglial cell elimination during pathology development and exhibits favorable pharmacokinetics across multiple animal species.

Related literature

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PMID: 31434879 PMCID: PMC6704256 DOI: 10.1038/s41467-019-11674-z

Negative feedback control of neuronal activity by microglia.

PMID: 32999463 PMCID: PMC7577179 DOI: 10.1038/s41586-020-2777-8

Astrocytic response to neural injury is larger during development than in adulthood and is not predicated upon the presence of microglia,

https://doi.org/10.1016/j.bbih.2019.100010

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