Divarasib | GDC-6036 | RG6330

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	$266.00	Visible after login	- +
2 mg	3-5 days	$406.00	Visible after login	- +
5 mg	3-5 days	$668.00	Visible after login	- +
10 mg	3-5 days	$1066.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5 days

$266.00

Visible after login

- +

2 mg

3-5 days

$406.00

Visible after login

- +

5 mg

3-5 days

$668.00

Visible after login

- +

10 mg

3-5 days

$1066.00

Visible after login

- +

Product Overview

Product Name	Divarasib (Synonyms: GDC-6036; RG6330)
CAS	2417987-45-0
Formula	C29H32ClF4N7O2
MW	622.06
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective inhibitor of the KRAS G12C mutation, boasting an IC50 of less than 0.01 μM. This investigational drug covalently binds to the switch II (SW-II) pocket of the KRAS G12C protein, effectively trapping it in an inactive GDP-bound state. By irreversibly locking the KRAS G12C oncoprotein in this inactive configuration, Divarasib inhibits tumor cell proliferation. It is currently under investigation for its potential use in treating solid tumors, including non-small cell lung cancer (NSCLC), colorectal cancer, and other malignancies.

Related literature

Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach.

Anal Chem. 2022 Sep 20;94(37):12927-12933.

Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.

PMID: 36876898 DOI: 10.1021/acs.analchem.2c04417

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History

CL3122

Divarasib (Synonyms: GDC-6036; RG6330)

2417987-45-0 98+%

Divarasib (Synonyms: GDC-6036; RG6330)

Chemical safety data sheet(MSDS)