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TEPP-46 (Synonyms: ML-265)

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Catalog No：CL3125 CAS No.：1221186-53-3 MDLNo：MFCD23160747 Formula：C17H16N4O2S2 MW：372.46

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5 days	$100.00	Visible after login	- +
10 mg	3-5 days	$152.00	Visible after login	- +
25 mg	3-5 days	$226.00	Visible after login	- +
50 mg	3-5 days	$326.00	Visible after login	- +

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Product Overview

Product Name	TEPP-46 (Synonyms: ML-265)
CAS	1221186-53-3
Formula	C17H16N4O2S2
MW	372.46
MDL	MFCD23160747
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

TEPP-46, also known as ML265, is a potent and selective PKM2 activator with an AC50 of 92 nM, exhibiting high selectivity over PKM1, PKR, and PKL.

Related literature

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

PMID: 22922757 PMCID: PMC3711671 DOI: 10.1038/nchembio.1060

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

PMID: 25565206 PMCID: PMC5198835 DOI: 10.1016/j.cmet.2014.12.005

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