Lercanidipine hydrochloride； CAS:132866-11-6

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Lercanidipine hydrochloride
CAS	132866-11-6
Formula	C36H42ClN3O6
MW	648.19
MDL	MFCD07773089
Appearance	Light yellow to yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Lercanidipine, a third-generation dihydropyridine calcium channel blocker, exhibits a pIC50 of 7.74 and features lipophilicity, brain penetration, and vascular selectivity . It demonstrates sustained antihypertensive effects, along with reno- and neuroprotection, and possesses antioxidant, anti-inflammatory, and anti-apoptotic properties, making it relevant for cardiovascular and neurological research.

Related literature

Neuroprotective effect of lercanidipine in middle cerebral artery occlusion model of stroke in rats.

Exp Neurol. 2017 Feb;288:25-37.

Calcium Channel Blockers--Benefits Upon Vascular Biology in Hypertensive Patients.

PMID: 26245661 DOI: 10.2174/187152571301150730115442

Lercanidipine and labedipinedilol--A attenuate lipopolysaccharide/interferon-γ-induced inflammation in rat vascular smooth muscle cells through inhibition of HMGB1 release and MMP-2, 9 activities.

PMID: 23290263 DOI: 10.1016/j.atherosclerosis.2012.12.005