buy Sibeprenlimab| Sibeprenlimab supplier | purchase Sibeprenlimab| Sibeprenlimab cost | Sibeprenlimab manufacturer | order Sibeprenlimab | Sibeprenlimab distributor; CAS: 2382896-07-1

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Sibeprenlimab (Synonyms: VIS649)
CAS	2382896-07-1
Storage condition	store at -80°C \| Shipping with blue ice.

Product details

Sibeprenlimab (VIS649), a humanized IgG2 monoclonal antibody, neutralizes APRIL, a key factor in IgA nephropathy (IgAN) pathogenesis. It effectively reduces pathogenic IgA and IgM while preserving vaccine responses to SARS-CoV-2 mRNA-based vaccines. Clinical trials demonstrate that sibeprenlimab decreases UPCR and stabilizes GFR, positioning it as a promising treatment for IgAN.

Related literature

Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency.

PMID: 37966286 DOI: 10.1056/NEJMoa2306263

A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence.

PMID: 37959392 PMCID: PMC10650434 DOI: 10.3390/jcm12216927

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VIS649 (Sibeprenlimab), an APRIL-Neutralizing IgG2 Monoclonal Antibody, in Healthy Volunteers.

PMID: 35570983 PMCID: PMC9091613 DOI: 10.1016/j.ekir.2022.01.1073

Sorry, no related items

History