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Product Overview

Product Name	Celastrol (Synonyms: Tripterine; Tripterin)
CAS	34157-83-0
Formula	C29H38O4
MW	450.61
MDL	MFCD03424073
Appearance	Red crystal powder
Storage condition	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year

Product details

Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.

Related literature

Celastrol Combats Methicillin‐Resistant Staphylococcus aureus by Targeting Δ1‐Pyrroline‐5‐Carboxylate Dehydrogenase

PMID: 37381655 PMCID: PMC10477891 DOI: 10.1002/advs.202302459

Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway.

PMID: 27049825 PMCID: PMC4829141 DOI: 10.3892/ijmm.2016.2549

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.

PMID: 16651429 DOI: 10.1158/0008-5472.CAN-05-4529

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History

HL1018

Celastrol (Synonyms: Tripterine; Tripterin)

34157-83-0 98+%