Naringenin 4'-O-β-D-Glucuronide is a natural compound derived from citrus fruits, particularly found in grapefruits and oranges. It is a metabolite of the flavonoid naringenin and exhibits various biological activities, including potential anticancer effects. This compound has been studied for its pharmacological properties, such as antioxidant, anti-inflammatory, and anti-carcinogenic activities. Recent research also suggests its potential as a new drug candidate against the COVID-19 Omicron variant based on molecular docking and dynamics studies. Naringenin 4'-O-β-D-Glucuronide is considered a valuable component in pharmaceutical research and development due to its natural origin and therapeutic potential.