Brefeldin A | BFA | Cyanein | Decumbin | 20350-15-6 | Autophagy

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	$136.00	Visible after login	- +
20 mg	In-stock	$206.00	Visible after login	- +
50 mg	3-5days	$368.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

10 mg

In-stock

$136.00

Visible after login

- +

20 mg

In-stock

$206.00

Visible after login

- +

50 mg

3-5days

$368.00

Visible after login

- +

Product Overview

Product Name	Brefeldin A (Synonyms: BFA ; Cyanein ; Decumbin)
CAS	20350-15-6
Formula	C16H24O4
MW	280.36
MDL	MFCD00083258
Appearance	Off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.

Related literature

Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells.

2014 Oct 29;19(11):17464-77.

Erythroleukemia cells acquire an alternative mitophagy capability.

PMID: 27091640 PMCID: PMC4835698 DOI: 10.1038/srep24641

Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS.

PMID: 23716697 PMCID: PMC3683763 DOI: 10.1073/pnas.1222413110

Small molecules enhance CRISPR genome editing in pluripotent stem cells.

PMID: 25658371 PMCID: PMC4461869 DOI: 10.1016/j.stem.2015.01.003

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History

CL1001

Brefeldin A (Synonyms: BFA ; Cyanein ; Decumbin)

20350-15-6 98+%

Brefeldin A (Synonyms: BFA ; Cyanein ; Decumbin)

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)