Product Name | Lenalidomide | CC-5013 |
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CAS | 191732-72-6 |
Formula | C13H13N3O3 |
MW | 259.26 |
Appearance | Off-white to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
500 mg | In-stock | $320.00 | Visible after login | |
1 g | In-stock | $400.00 | Visible after login | |
5 g | In-stock | $1200.00 | Visible after login |
Product Name | Lenalidomide | CC-5013 |
---|---|
CAS | 191732-72-6 |
Formula | C13H13N3O3 |
MW | 259.26 |
Appearance | Off-white to light yellow powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.