Alectinib | CH5424802 | RO5424802 | RG7853 | CAS 1256580-46-7

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
250 mg	In-stock	$188.00	Visible after login	- +
500 mg	In-stock	$288.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

250 mg

In-stock

$188.00

Visible after login

- +

500 mg

In-stock

$288.00

Visible after login

- +

Product Overview

Product Name	Alectinib \| CH5424802 \| RO5424802 \| RG7853
CAS	1256580-46-7
Formula	C30H34N4O2
MW	482.62
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.

Related literature

CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.

PMID: 21575866 DOI: 10.1016/j.ccr.2011.04.004

Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study.

PMID: 30215676 PMCID: PMC6290889 DOI: 10.1093/annonc/mdy405