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Selamectin | Revolution | Stronghold | 165108-07-6

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Catalog No：CL1661 CAS No.：220119-17-5 MDLNo： Formula：C43H63NO11 MW：769.96

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Product Overview

Product Name	Selamectin \| Revolution \| Stronghold \| 165108-07-6
CAS	220119-17-5
Formula	C43H63NO11
MW	769.96
Appearance	White to off-white powder

Product details

Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀ of 120 nM

Related literature

First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions.

PMID: 30746583 DOI: 10.1007/s00436-019-06248-3

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Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.

PMID: 15953199 DOI: 10.1111/j.1365-2885.2005.00655.x

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