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Adezmapimod (Synonyms: SB 203580; RWJ 64809;PB 203580)

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Catalog No：CL1853 CAS No.：152121-47-6 MDLNo： Formula：C21H16FN3OS MW：377.43

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20 mg	In-stock	$300.00	Visible after login	- +
50 mg	3-5days	$500.00	Visible after login	- +

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Product Overview

Product Name	Adezmapimod (Synonyms: SB 203580; RWJ 64809;PB 203580)
CAS	152121-47-6
Formula	C21H16FN3OS
MW	377.43
Appearance	White to light yellow
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.

Related literature

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.

PMID: 10702313 DOI: 10.1074/jbc.275.10.7395

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A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis.

PMID: 24216180 PMCID: PMC3946852 DOI: 10.1016/j.molonc.2013.10.003

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Specificity and mechanism of action of some commonly used protein kinase inhibitors.

PMID: 10998351 PMCID: PMC1221339 DOI: 10.1042/0264-6021:3510095

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