Adezmapimod Hydrochloride | SB 203580 Hydrochloride | RWJ 64809 Hydrochloride

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Adezmapimod Hydrochloride (Synonyms: SB 203580 hydrochloride; RWJ 64809 hydrochloride)
CAS	869185-85-3
Formula	C21H17ClFN3OS
MW	413.90
Appearance	Light yellow to yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator.