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Sitagliptin phosphate | MK-0431 phosphate

ChemLeader 98+%

Catalog No：CL1855A CAS No.：654671-78-0 MDLNo： Formula：C16H15F6N5O·H3O4P MW：505.31 | 407.32(free)

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Product Overview

Product Name	Sitagliptin phosphate \| MK-0431 phosphate
CAS	654671-78-0
Formula	C16H15F6N5O·H3O4P
MW	505.31 \| 407.32(free)
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture and light

Product details

Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC₅₀ of 19 nM in Caco-2 cell extracts.

Related literature

Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue.

PMID: 22186413 DOI: 10.1210/en.2011-1732

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice.

PMID: 18299314 DOI: 10.2337/db07-1639

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