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SB-743921 free base

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Catalog No：CL2422A CAS No.：618430-39-0 MDLNo： Formula：C31H33ClN2O3 MW：517.06

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Product Overview

Product Name	SB-743921 free base
CAS	618430-39-0
Formula	C31H33ClN2O3
MW	517.06

Product details

SB-743921 (SB-921) is an inhibitor of Kinesin Spindle Protein (KSP), a mitotic protein essential for cell cycle control and motility. It functions by selectively targeting rapidly dividing cells and disrupting spindle formation during cell division, leading to G2/M phase arrest and ultimately causing cell death. It also inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cell lines.

Related literature

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer.

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.

PMID: 25146433 DOI: 10.3109/10428194.2014.956319

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

PMID: 23394180 PMCID: PMC3759169 DOI: 10.1021/jm3014597