Romidepsin (Synonyms: FK 228; FR 901228; NSC 630176)； CAS: 128517-07-7

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Product Overview

Product Name	Romidepsin (Synonyms: FK 228; FR 901228; NSC 630176; Depsipeptide)
CAS	128517-07-7
Formula	C24H36N4O6S2
MW	540.70
MDL	MFCD18433404
Appearance	White to off-white powder

Product details

Romidepsin (FR 901228) is an HDAC inhibitor targeting HDAC1/2/4/6 with IC50 values of 36/47/510/1400 nM. It has antitumor activity and is used to treat peripheral and cutaneous T-cell lymphomas.Romidepsin (FK 228), derived from Chromobacterium violaceum, induces G2/M cell cycle arrest and apoptosis.
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Related literature

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

PMID: 12208741

Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells.

Biochem Pharmacol. 2017 Mar 1;127:90-100.

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History

CL1922

Romidepsin (Synonyms: FK 228; FR 901228; NSC 630176; Depsipeptide)

128517-07-7 98+%