Product Name | Tacrolimus | Fujimycin | FR900506 | FK506 |
---|---|
CAS | 104987-11-3 |
Formula | C44H69NO12 |
MW | 804.02 |
Appearance | White to off-white powder |
Storage condition | 4°C, protect from light |
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Product Name | Tacrolimus | Fujimycin | FR900506 | FK506 |
---|---|
CAS | 104987-11-3 |
Formula | C44H69NO12 |
MW | 804.02 |
Appearance | White to off-white powder |
Storage condition | 4°C, protect from light |
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
PMID: 27518770 PMCID: PMC5114712 DOI: 10.1007/s10545-016-9959-4
Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo.
PMID: 24912495 PMCID: PMC4094770 DOI: 10.3892/mmr.2014.2302
PMID: 22130237 DOI: 10.1248/bpb.34.1823