| Product Name | Paricalcitol |
|---|---|
| CAS | 131918-61-1 |
| Formula | C27H44O3 |
| MW | 416.64 |
| MDL | MFCD08067734 |
| Appearance | White to off-white powder |
| Storage condition | 4°C, protect from light, stored under nitrogen |
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
|---|---|---|---|---|---|
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| Product Name | Paricalcitol |
|---|---|
| CAS | 131918-61-1 |
| Formula | C27H44O3 |
| MW | 416.64 |
| MDL | MFCD08067734 |
| Appearance | White to off-white powder |
| Storage condition | 4°C, protect from light, stored under nitrogen |
Paricalcitol, a selective VDR agonist, effectively suppresses PTH mRNA and inhibits parathyroid cell growth, treating secondary hyperparathyroidism in CKD. It's also associated with lower morbidity and improved survival rates compared to other VDRAs, with a favorable side-effect profile. Additionally, paricalcitol exhibits anti-inflammatory effects, potentially beneficial in managing CKD-related inflammation.
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In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation.
PMID: 22874762 DOI: 10.1152/ajprenal.00684.2011
PMID: 22800987 DOI: 10.1016/j.jsbmb.2012.06.004