Fludarabine | Fara A | Fludarabinum | Fludarabine | F-ara-A | NSC 118218 Base | STAT inhibitor

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Price(USD)

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Product Overview

Product Name	Fludarabine \| Fara A \| Fludarabinum \| Fludarabine \| F-ara-A \| NSC 118218 Base
CAS	21679-14-1
Formula	C10H12FN5O4
MW	285.23
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.

Related literature

Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type.

PMID: 28901399 DOI: 10.3892/mmr.2017.7384

Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases.

PMID: 12764376 DOI: 10.1038/sj.leu.2402895

Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia.

PMID: 12969985 DOI: 10.1182/blood-2003-05-1449

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History

CL3046

21679-14-1 98+%