Everolimus | RAD-001 | 依维莫司

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	$76.00	Visible after login	- +
25 mg	In-stock	$126.00	Visible after login	- +

Product Overview

Product Name	Everolimus \| RAD-001
CAS	159351-69-6
Formula	C53H83NO14
MW	958.22
MDL	MFCD00929329
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Security information

Product details

Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.

Related literature

Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes,Limitations, and Further Proposals.

PMID: 20360931 PMCID: PMC2847314 DOI: 10.1593/tlo.09277

Everolimus | RAD-001

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)