Product Name | Combretastatin A4 Disodium Phosphate(CA4P) |
---|---|
CAS | 168555-66-6 |
Formula | C18H19PO8Na2 |
MW | 440.29 |
Appearance | White powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
10 mg | In-stock | $500.00 | Visible after login | |
20 mg | In-stock | $800.00 | Visible after login | |
50 mg | In-stock | $1260.00 | Visible after login |
Product Name | Combretastatin A4 Disodium Phosphate(CA4P) |
---|---|
CAS | 168555-66-6 |
Formula | C18H19PO8Na2 |
MW | 440.29 |
Appearance | White powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.