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SB-743921

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Catalog No：CL2422 CAS No.：940929-33-9 MDLNo： Formula：C31H34Cl2N2O3 MW：553.52

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Product Overview

Product Name	SB-743921
CAS	940929-33-9
Formula	C31H34Cl2N2O3
MW	553.52
Appearance	Off-white to yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

SB743921 is a kinesin spindle protein (KSP) inhibitor with K_i of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

Related literature

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer.

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.

PMID: 25146433 DOI: 10.3109/10428194.2014.956319

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

J Med Chem. 2013 Mar 14;56(5):1878-93.