Prucalopride（Synonyms: R093877;Motegrity; Resolor; Resotran; 普卢卡必利; 普卡必利;CAS: 179474-81-8; MDL: MFCD09837787

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Product Overview

Product Name	Prucalopride（Synonyms: R093877;Motegrity; Resolor; Resotran; 普卢卡必利; 普卡必利）
CAS	179474-81-8
Formula	C18H26ClN3O3
MW	367.87
MDL	MDL: MFCD09837787
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.

Related literature

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway.

PMID: 29866060 PMCID: PMC5985575 DOI: 10.1186/s12883-018-1083-7

A placebo-controlled trial of prucalopride for severe chronic constipation.

PMID: 18509121 DOI: 10.1056/NEJMoa0800670

Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats.

PMID: 35543167 PMCID: PMC9162040 DOI: 10.3892/ijmm.2022.5143

Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.

PMID: 31640407 DOI: 10.1177/0960327119883409

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History

CL2585

Prucalopride（Synonyms: R093877;Motegrity; Resolor; Resotran; 普卢卡必利; 普卡必利）

179474-81-8 98+%

Prucalopride（Synonyms: R093877;Motegrity; Resolor; Resotran; 普卢卡必利; 普卡必利）

Chemical safety data sheet(MSDS)