Home > Category > Signaling Pathways > Antibody-drug Conjugate/ADC Related > ADC Payload (ADC Cytotoxin) > Thailanstatin A

Thailanstatin A

ChemLeader 98+%
Catalog No:CL3467 CAS No.:1426953-21-0 MDLNo: Formula:C28H41NO9 MW:535.63
Size Availability Price(USD) VIP Price (USD) Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Chemical safety data sheet(MSDS)

Download MSDS
  • Product Overview
  • Related documents
  • Product details
  • Related literature
Product Overview
Product Name Thailanstatin A
CAS1426953-21-0
FormulaC28H41NO9
MW535.63
Product details

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.

Related literature
Sorry, there is no relevant literature
Related
Sorry, no related items
Service
ChemLeader
021-58180488
Online service time: 9:00-18:00 on weekdays