| Product Name | Thailanstatin A |
|---|---|
| CAS | 1426953-21-0 |
| Formula | C28H41NO9 |
| MW | 535.63 |
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | |
|---|---|---|---|---|---|
|
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible. |
|||||
| Product Name | Thailanstatin A |
|---|---|
| CAS | 1426953-21-0 |
| Formula | C28H41NO9 |
| MW | 535.63 |
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.