TW-37

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Size

Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	TW-37
CAS	877877-35-5
Formula	C33H35NO6S
MW	573.70
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.

Related literature

Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.

PMID: 16951185 DOI: 10.1158/0008-5472.CAN-05-3691

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

PMID: 17404107 DOI: 10.1158/1078-0432.CCR-06-1574

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History

SP600125 (Synonyms: Nsc75890; SP 600125; Anthra[1,9-cd]pyrazol-6(2H)-one;1,9-Pyrazoloanthrone; Anthrapyrazolone)

129-56-6 98+%

Chemical safety data sheet(MSDS)