Barasertib-HQPA (Synonyms: AZD2811; INH-34; AZD1152-HQPA); CAS: 722544-51-6

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Product Overview

Product Name	Barasertib-HQPA (Synonyms: AZD2811; INH-34; AZD1152-HQPA)
CAS	722544-51-6
Formula	C26H30FN7O3
MW	507.56
MDL	MFCD17392583
Appearance	White to yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

Barasertib-HQPA (AZD2811) is a highly selective Aurora kinase B inhibitor with an IC50 value of 0.37 nM in cell-free assays. Barasertib-HQPA (AZD2811) has the potential to induce growth arrest and apoptosis in cancer cells.

Related literature

Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J].

https://doi.org/10.1016/j.ejps.2021.105786

AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy.

PMID: 25277659 DOI: 10.1007/s13277-014-2664-8

AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo.

PMID: 19366807 PMCID: PMC2684546 DOI: 10.1158/0008-5472.CAN-08-3203

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History

CL3116

Barasertib-HQPA (Synonyms: AZD2811; INH-34; AZD1152-HQPA)

722544-51-6 98+%