AZD-7648

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5 days	$98.00	Visible after login	- +
10 mg	3-5 days	$130.00	Visible after login	- +
25 mg	3-5 days	$236.00	Visible after login	- +
50 mg	3-5 days	$376.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

3-5 days

$98.00

Visible after login

- +

10 mg

3-5 days

$130.00

Visible after login

- +

25 mg

3-5 days

$236.00

Visible after login

- +

50 mg

3-5 days

$376.00

Visible after login

- +

Product Overview

Product Name	AZD-7648
CAS	2230820-11-6
Formula	C18H20N8O2
MW	380.40
MDL	MFCD32062688
Appearance	White to yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

AZD-7648 is a potent, orally active, and selective DNA-PK inhibitor with an IC50 of 0.6 nM, demonstrating significant antitumor activity.This compound induces apoptosis and enhances the effects of radiation and chemotherapy, making it a promising therapeutic agent for myeloid leukemias.In addition to its cytotoxic effects, AZD-7648 also triggers cell cycle arrest, further contributing to its antitumor properties.

Related literature

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.

PMID: 31699977 PMCID: PMC6838110 DOI: 10.1038/s41467-019-12836-9

Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.

PMID: 34011558 PMCID: PMC9401489 DOI: 10.1158/1078-0432.CCR-20-3701

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History

CL3127

AZD-7648

2230820-11-6 98+%

Chemical safety data sheet(MSDS)