Salvicine

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Product Overview

Product Name	Salvicine
CAS	240423-23-8
Formula	C20H26O4
MW	330.42

Product details

Salvicine is a natural compound that displays cytotoxicity in human osteosarcoma cells. Salvicine binds to DNA and inhibits the polymerase activity of DNA gyrase, preventing transcription and replication. Salvicine also shows inhibitory effects on the p21 protein, which is an important regulator of G1-phase progression in the cell cycle. Salvicine could be used as a potential drug target for cancer treatment.

Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell.Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin.

Related literature

Anti-angiogenic activity of salvicine.

PMID: 23750780 DOI: 10.3109/13880209.2013.776612

Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effects by trapping enzyme-DNA cleavage complexes.

PMID: 11551518 DOI: 10.1016/s0006-2952(01)00732-8

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