Nintedanib supplier | BIBF 1120 manufacturer | Intedanib distributor | CAS 656247-17-5

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
500 mg	In-stock	$336.00	Visible after login	- +
1 g	In-stock	$498.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

500 mg

In-stock

$336.00

Visible after login

- +

1 g

In-stock

$498.00

Visible after login

- +

Product Overview

Product Name	Nintedanib (Synonyms: BIBF 1120; Intedanib)
CAS	656247-17-5
Formula	C31H33N5O4
MW	539.62
MDL	MFCD11974012
Appearance	Yellow crystalline powder

Product details

Nintedanib, also known as BIBF 1120, is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR). Intedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration.
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Related literature

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

PMID: 19522465 DOI: 10.1021/jm900431g

BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.

Cancer Res, 2008, 68(12), 4774-4782.