Bortezomib | PS-341 | LDP-341 | NSC 681239

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
100 mg	In-stock	$108.00	Visible after login	- +
500 mg	In-stock	$366.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

100 mg

In-stock

$108.00

Visible after login

- +

500 mg

In-stock

$366.00

Visible after login

- +

Product Overview

Product Name	Bortezomib \| PS-341 \| LDP-341 \| NSC 681239
CAS	179324-69-7
Formula	C19H25BN4O4
MW	384.24
MDL	MFCD09056737
Appearance	White to off-white solid
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Bortezomib is a potent 20S proteasome inhibitor with K_i of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

Related literature

Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects.

PMID: 22016836 PMCID: PMC3196288

Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line.

PMID: 21472244 DOI: 10.3892/mmr_00000262

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status.

PMID: 16166592 DOI: 10.1182/blood-2005-05-2091

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History

CL1031

Bortezomib | PS-341 | LDP-341 | NSC 681239

179324-69-7 99+%

Bortezomib | PS-341 | LDP-341 | NSC 681239

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)