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Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239)

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Catalog No：CL1031 CAS No.：179324-69-7 MDLNo：MFCD09056737 Formula：C19H25BN4O4 MW：384.24

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100 mg	In-stock	$108.00	Visible after login	- +
500 mg	In-stock	$366.00	Visible after login	- +

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Product Overview

Product Name	Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239)
CAS	179324-69-7
Formula	C19H25BN4O4
MW	384.24
MDL	MFCD09056737
Appearance	White to off-white solid
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Bortezomib is a potent 20S proteasome inhibitor with K_i of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
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Related literature

Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects.

PMID: 22016836 PMCID: PMC3196288

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Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line.

PMID: 21472244 DOI: 10.3892/mmr_00000262

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The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status.

PMID: 16166592 DOI: 10.1182/blood-2005-05-2091

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