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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	$67.00	Visible after login	- +
2 mg	3-5 days	$101.00	Visible after login	- +
5 mg	3-5 days	$166.00	Visible after login	- +
10 mg	3-5 days	$260.00	Visible after login	- +
25 mg	3-5 days	$416.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5 days

$67.00

Visible after login

- +

2 mg

3-5 days

$101.00

Visible after login

- +

5 mg

3-5 days

$166.00

Visible after login

- +

10 mg

3-5 days

$260.00

Visible after login

- +

25 mg

3-5 days

$416.00

Visible after login

- +

Product Overview

Product Name	Nemorubicin \| Methoxymorpholinyldoxorubicin \| PNU 152243 \| PNU-152243A \| \| DMM Dox \| MMRDX \| FCE 23762 \| PNU 152243
CAS	108852-90-0
Formula	C32H37NO13
MW	643.64
MDL	MFCD00871079
Appearance	Orange to reddish brown powder
Storage condition	4°C, protect from light

Product details

Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity.

Related literature

Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.

PMID: 15746066 DOI: 10.1158/1078-0432.CCR-04-1845

Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells.

PMID: 20868484 PMCID: PMC2955619 DOI: 10.1186/1476-4598-9-259

In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes.

PMID: 18671948 DOI: 10.1016/j.bcp.2008.07.003

Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer.

PMID: 19011599 PMCID: PMC2669851 DOI: 10.1038/cgt.2008.93

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