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Reparixin | Repertaxin | DF 1681Y

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Catalog No：CL1110 CAS No.：266359-83-5 MDLNo： Formula：C14H21NO3S MW：283.39

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Product Overview

Product Name	Reparixin \| Repertaxin \| DF 1681Y
CAS	266359-83-5
Formula	C14H21NO3S
MW	283.39
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC₅₀s of 1 and 100 nM, respectively.

Related literature

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor.

PMID: 21718305 PMCID: PMC3268197 DOI: 10.1111/j.1476-5381.2011.01566.x

Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2.

PMID: 17665889 DOI: 10.1021/jm061469t

Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice.

PMID: 23644861 PMCID: PMC3611745 DOI: 10.6061/clinics/2013(03)oa17