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Halofuginone hydrobromide (Synonyms: RU-19110 hydrobromide)

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Catalog No:CL1455A CAS No.:64924-67-0 MDLNo: Formula:C16H18Br2ClN3O3 MW:495.59
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Product Overview
Product Name Halofuginone hydrobromide (Synonyms: RU-19110 hydrobromide)
CAS64924-67-0
FormulaC16H18Br2ClN3O3
MW495.59
Product details

Halofuginone (RU-19110) hydrobromide, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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