Home > Category > Signaling Pathways > Microbiology/Virology/Anti-infection > SARS-CoV > Sivelestat sodium (Synonyms: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium;Sivelestat Sodium Anhydrous)

Sivelestat sodium (Synonyms: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium;Sivelestat Sodium Anhydrous)

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Catalog No：CL1815B CAS No.：150374-95-1 MDLNo： Formula：C20H21N2NaO7S MW：456.44

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Product Overview

Product Name	Sivelestat sodium (Synonyms: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium;Sivelestat Sodium Anhydrous)
CAS	150374-95-1
Formula	C20H21N2NaO7S
MW	456.44
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Related literature

ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun.

PMID: 2049103 DOI: 10.1016/0006-291x(91)91862-7

Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.

PMID: 18165924 DOI: 10.1007/s11010-007-9698-9

Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

PMID: 32860252 DOI: 10.1111/jcpt.13251