Abrocitinib | PF-04965842 |CAS: 1622902-68-4 | JAK inhibitor

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	In-stock	$78.00	Visible after login	- +
5 mg	In-stock	$188.00	Visible after login	- +
10 mg	In-stock	$288.00	Visible after login	- +
25 mg	In-stock	$488.00	Visible after login	- +
50 mg	In-stock	$688.00	Visible after login	- +
100 mg	In-stock	$956.00	Visible after login	- +
250 mg	In-stock	$1066.00	Visible after login	- +
500 mg	In-stock	$1666.00	Visible after login	- +
1 g	In-stock	$2366.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

In-stock

$78.00

Visible after login

- +

5 mg

In-stock

$188.00

Visible after login

- +

10 mg

In-stock

$288.00

Visible after login

- +

25 mg

In-stock

$488.00

Visible after login

- +

50 mg

In-stock

$688.00

Visible after login

- +

100 mg

In-stock

$956.00

Visible after login

- +

250 mg

In-stock

$1066.00

Visible after login

- +

500 mg

In-stock

$1666.00

Visible after login

- +

1 g

In-stock

$2366.00

Visible after login

- +

Product Overview

Product Name	Abrocitinib (Synonyms: PF-04965842; N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide \| N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide)
CAS	1622902-68-4
Formula	C14H21N5O2S
MW	323.41
MDL	MFCD30187577
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC₅₀s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC₅₀, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Related literature

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

PMID: 29298069 DOI: 10.1021/acs.jmedchem.7b01598

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History

CL2918

Abrocitinib (Synonyms: PF-04965842; N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide)

1622902-68-4 Purity: 99.08%

Abrocitinib (Synonyms: PF-04965842; N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}-propane-1-sulfonamide)

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)