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HRO761 | Werner syndrome RecQ helicase-IN-1

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Catalog No：CL2980 CAS No.：2869954-34-5 MDLNo： Formula：C31H31ClF3N9O5 MW：702.08

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$126.00	Visible after login	- +
2 mg	3-5days	$156.00	Visible after login	- +
5 mg	3-5days	$266.00	Visible after login	- +

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Product Overview

Product Name	HRO761 \| Werner syndrome RecQ helicase-IN-1
CAS	2869954-34-5
Formula	C31H31ClF3N9O5
MW	702.08
Appearance	White to light yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.

Related literature

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

PMID: 38658754 PMCID: PMC11078746 DOI: 10.1038/s41586-024-07350-y

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CL2980

HRO761 | Werner syndrome RecQ helicase-IN-1

2869954-34-5 98+%